A global study of more than 28,000 people published in European Heart Journal has provided the strongest evidence to date for the link between high blood pressure and dementia risk.
This is significant because while there are limited treatment breakthroughs for dementia, reducing the risk of developing this disease is a welcome step forward.
“Our study suggests that using readily available treatments to lower blood pressure is currently one of our ‘best bets’ to tackle this insidious disease,” Dr Ruth Peters, Associate Professor at UNSW Sydney and Program Lead for Dementia in The George Institute’s Global Brain Health Initiative, said.
Dr Peters says that while many trials have looked at the health benefits of lowering blood pressure, not many included dementia outcomes and even fewer were placebo-controlled.
“Most trials were stopped early because of the significant impact of blood pressure lowering on cardiovascular events, which tend to occur earlier than signs of dementia,” she said.
Examining the relationship between BP and dementia
To examine the relationship between blood pressure and dementia more closely, researchers analysed five double-blind placebo-controlled randomised trials that used different blood pressure-lowering treatments and followed patients until the development of dementia.
A total of 28,008 individuals with an average age of 69 and a history of high blood pressure from 20 countries were included.
Across these studies, the mid-range of follow-up was just over four years.
“We found there was a significant effect of treatment in lowering the odds of dementia associated with a sustained reduction in blood pressure in this older population,” Dr Peters said.
“Our results imply a broadly linear relationship between blood pressure reduction and lower risk of dementia, regardless of which type of treatment was used.”
Dementia public health measures
Researchers hope the results will help in designing public health measures to slow the advance of dementia as well as informing treatment, where there may be hesitations around how far to lower blood pressure in older age.
“Our study provides the highest grade of available evidence to show that blood pressure lowering treatment over several years reduces the risk of dementia, and we did not see any evidence of harm,” Dr Peters said.
“But what we still don’t know is whether additional blood pressure lowering in people who already have it well-controlled or starting treatment earlier in life would reduce the long-term risk of dementia.”
Professor Craig Anderson, Director of the Global Brain Health program at The George Institute said: “This work is an important foundation for clinical trials to provide reliable estimates of the benefits and risks of preventative treatments, and how best to apply them across different populations.”
