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WHAT IS UC-II® COLLAGEN?
UC-II® Collagen is a novel form of undenatured type II collagen, the type of collagen found in cartilage. It is made by a patented manufacturing process designed to preserve is native structure, allowing UC-II® to work with the immune system to enhance healthy joint function, promoting the body’s own repair process.
HOW DOES UC-II® COLLAGEN WORK?
UC-II® works with the immune system to induce oral tolerance, this contributes to decreased inflammatory response leading to improved joint comfort and function.2-4
STEP 1 – BIND: UC-II® collagen travels through the gut to a collection of immune cells in the small intestine called Peyer’s patches. The bioactive regions of UC-II® collagen, called epitopes, bind to the immune cells within the Peyer’s patch inducing the oral tolerance process.
STEP 2 – TRIGGER: When these epitopes bind to the Peyer’s patches, it triggers an immune response, stimulating the production of regulatory T cells.
STEP 3 – BUILD: Regulatory T cells travel to the joints, releasing cytokines, regulating the inflammation response and upregulating chondrocytes to help promote joint cartilage growth
HOW IS UC-II® COLLAGEN DIFFERENT FROM OTHER JOINT SUPPLEMENTS?Caltrate Joint Health contains ingredients that not only supplement to support joint health, it also contains UC-II collagen too which works with the immune system to help improve joint health, via prompting the body’s natural processes to repair joint cartilage.
| Ingredient | Mode of Action | Dose Size |
| UC-II® Collagen | Triggers immune system to repair joint cartilage | Small, 40mg |
| Hydrolysed Collagen | Supplements body’s natural collagen | Very large, from 2,000 – 10,000 mg |
| Glucosamine & Chondroitin | Supplements body’s natural glucosamine & chondroitin | Large, up to 1,500 mg |
| Curcumin | Reduces inflammation | Large, up to 2,000 mg |
WHAT ARE THE BENEFITS OF CALTRATE JOINT HEALTH?
Caltrate Joint Health has a 3-IN-1 TRIPLE BENEFIT:
- UC-II® collagen helps enhance joint health and reduces mild joint pain associated with symptoms of mild arthritis
- Vitamin C for collagen formation to promote joint mobility
- Manganese for healthy connective tissue development and UC-II® collagen supports cartilage recovery
References
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Crowley et al 2009 Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int. J. Med. Sci
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Martínez-Puig, D., Costa-Larrión, E., Rubio-Rodríguez, N. and Gálvez-Martín, P., 2023. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients, 15(6), p.1332.)
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Asnagli H, Martire D, Belmonte N, et al. Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis. Arthritis Res Ther. 2014;16(3):R115. PMID: 24886976.
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Müller RD, John T, Kohl B, et al. IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro. Cytokine. 2008;44(3):377-85. PMID: 19026560.
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