Participants sought for healthy ageing microbiome trial

Researchers from UNSW Sydney are seeking more than 150 Sydney-based adults aged 60-70 years for a trial seeking to understand if taking dietary supplements can help improve frailty and inflammation.

The Frailty, Ageing and Inflammation Trial for Health (FAITH) is being led by the School of Population Health at UNSW Sydney, Neuroscience Research Australia (NeuRA), and the Microbiome Research Centre (MRC), St George & Sutherland Clinical School.

Meeting dietary guidelines can become more challenging with ageing and in particular lower fruit, vegetable and fibre intakes are observed, which leads to a reduction in the production of beneficial short chain fatty acids.

Short chain fatty acids are important in influencing the microbiome. In the absence of these fatty acids, the body is unable to dampen down inflammation, which may promote the onset of age-related illnesses.

“Diet plays a fundamental role in shaping the gut microbiome, and diet and nutritional status are among the most important, modifiable determinants of human health.

“It is exciting that we are starting to understand the links between brain, body and gut health,” says lead investigator Dr Adrienne Withall.

The FAITH study will provide valuable information about whether key nutrients can improve low grade inflammation and affect the microbiome in older Australian adults.

The hypothesis underlying this research has come from over 18 years of clinical experience from dietitian, Milena Katz.

This research is the focus of Milena’s PhD and she approached a major Australian supplement provider to see if they would donate the products to enable her to test her theory.

“They liked our proposed trial and agreed to donate their supplements. Now we need people to get involved,” says Ms Katz.

“Importantly, this information will help to inform medical dietary therapy to help older people to age well.”

The call for participation comes at a time when good nutrition has become a focus for older Australians as the The Royal Commission into Aged Care Quality and Safety’s final report is publicly released.

Participation in the FAITH trial involves a biological sample collection at the start and end of the trial, completing surveys and taking nutritional supplements for four months.

All participants enrolled in the study receive a four months’ supply of dietary supplements, regular monitoring and dietary advice.

The participants allocated into the control group will receive the intervention supplements after the trial is completed.

To find out more about the trial, contact study coordinator Milena Katz at 

For more information about MRC’s work, visit:


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